Electrical Stimulation During Immobilization (ESDIM)

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Disuse Atrophy; Neuromuscular Electrical Stimulation; Immobilization

Treatments: Behavioral: immobilization

Study type: Interventional

Funder types: Other

Identifiers

NCT01513486

MEC 11-3-073

Details and patient eligibility

About

In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion criteria

• Smoking
• Performing regular resistance training in the previous 6 months
• Hypertension (according to WHO criteria) [46] and/or cardiovascular disease
• Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
• Use of any prescribed medication
• Type 2 diabetes mellitus
• Any family history of thrombosis
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Myocardial infarction within the last 3 years
• Use of anti-coagulants

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups, including a placebo group

Immobilization with NMES

Experimental group

Description:

Immobilization with daily NMES

Treatment:

Behavioral: immobilization

Immobilization without NMES

Placebo Comparator group

Description:

Immobilization without daily NMES

Treatment:

Behavioral: immobilization