Electroacupuncture Treatment of Behavioral and Psycological Symptoms in Patients With Alzheimer's Disease

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Status: Not yet enrolling

Conditions: Alzheimer's Dementia; BPSD (Behavioral and Psycological Symptoms of Dementia)

Treatments: Other: Electroacupuncture treatment

Study type: Observational

Funder types: Other

Identifiers

NCT06523309

2024-076-KY-01

Details and patient eligibility

About

This study aims to establish a prospective case registration research platform for electroacupuncture in treating behavioral and psychological symptoms in patients with mild to moderate Alzheimer's disease, and to investigate the dose-effect relationship and cost-effectiveness of electroacupuncture for these symptoms.

Full description

To establish a prospective case registration research platform aimed at treating mild to moderate Alzheimer's disease patients presenting with behavioral and psychological symptoms. This platform will document the electroacupuncture treatment process, conduct regular assessments using neuropsychiatric questionnaires (NPI) and the Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change Scale (ADAS-CGIC), and compare the effects of different parameters, treatment frequency, and duration of electroacupuncture on therapeutic outcomes for various behavioral and psychological symptoms in Alzheimer's disease patients. Furthermore, it aims to investigate the influencing factors of electroacupuncture treatment for behavioral and psychological symptoms.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Meet the diagnostic criteria for AD in the NIA-AA standard;
2. Clinical dementia rating scale ≤2 points;
3. Accompanied by at least one psychobehavioral symptom, NPI：frequency × degree ≥1 point;
4. Sign informed consent.

Exclusion criteria

1.There are contraindications for acupuncture treatment, such as the tendency of acupoint bleeding or allergy to metal

Trial design

1,000 participants in 4 patient groups

Affective symptom group

Description:

A group of Alzheimer's patients showing emotional symptoms such as anxiety, depression, apathy, etc.

Treatment:

Other: Electroacupuncture treatment

Psychotic symptom group

Description:

A group of Alzheimer's patients showing psychotic symptoms such as delusions, hallucinations, etc.

Treatment:

Other: Electroacupuncture treatment

Hyperactivity symptom group

Description:

A group of Alzheimer's patients showing hyperactivity symptoms such as irritability, aggression, aberrant motor behaviour, etc.

Treatment:

Other: Electroacupuncture treatment

Euphoric symptom group

Description:

A group of Alzheimer's patients showing euphpric symptoms.

Treatment:

Other: Electroacupuncture treatment