Electrochemistry Measurement of Skin Hydration Parameters (SKINBIOSENSE)

Assistance Publique - Hôpitaux de Paris

Status: Unknown

Conditions: Atopic Dermatitis; Acne; Skin Electrochemistry

Treatments: Other: Collects of skin's hydration

Study type: Interventional

Funder types: Other

Identifiers

NCT05071456

APHP210446

Details and patient eligibility

About

To date measuring the effect of dermocosmetic products on the main identified factors of aging and alteration of the skin barrier is based on invasive and expensive experiments. Electrochemistry enables to measure a specific signal for a substance of interest e.g. Vitamin C using an surface contact with an electrode.

Therefore, this study will evaluate the reliability and feasibility of measurements of skin's hydration parameters such as NMF and squalene using electrochemistry. These study will be made on three groups of individuals with different skin types: dry skin i.e. atopic dermatitis patients, oily skin i.e. acne skin and a control group of individual without facial dermatosis. Collects of parameters of interest will be made by using patch using electrochemistry (contact with an electrode and potentiostat to detect an electric signal) . It is a simple method that relies on a sensor / electrode pair that allows a study of the surface molecules of the skin. Application in the measurement of vitamin C in food products has already been validated.

On a second hand, a collect by chromatography of the parameters of interest will be carried out in order to compare the new method with the reference method.

This procedure has been developed via a procedure including collecting surface parameters using a patch an developping special electrodes and miniaturized detecting signal tool (potentiostat)

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 ≤ Age ≤ 70
• Subjects with past history or follow-up for acne or rosacea stage I ou II, atopic dermatitis mild to moderate without immunosuppressive treatment
• Subjects enabling to perform a one day visit at the hospital
• Written consent according to local regulatory requirements
• Affiliated to a social security scheme

Exclusion criteria

• Pregnant women or breastfeeding
• Patient under guardianship or curatorship, legal protection or protection of justice
• Participation in other interventional research on skin moisturizer

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

Atopic dermatitis patients

Experimental group

Treatment:

Other: Collects of skin's hydration

Patient with oily acne skin

Experimental group

Treatment:

Other: Collects of skin's hydration

Control group of patient without facial dermatosis

Active Comparator group

Treatment:

Other: Collects of skin's hydration