Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes

Hospital Sao Domingos

Status: Completed

Conditions: Sepsis

Treatments: Diagnostic Test: Eletroencephalography

Study type: Observational

Funder types: Other

Identifiers

NCT05448534

54

Details and patient eligibility

About

The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients after 3 months of ICU discharge..

Full description

The investigators prospectively evaluate patients with sepsis and septic shock expected to stay in the intensive care unit (ICU) for at least 4 days. We used Sinek and Young scales to classify electroencephalographic patterns during ICU stay (in the first 24 hours after admission and in the third ICU day) and correlate with cognitive outcome evaluated with MOCA score 3 months after ICU discharge. The investigators evaluate as primary outcome the association between electroencephalographic abnormalities and cognitive dysfunction measured by the Montreal Cognitive Assessment (MoCA) 3 months after ICU discharge and secondary outcomes as association between electroencephalographic patterns and 28 days mortality, Quality of Life (SF-36) after 3 months of discharge, ventilator free days, vasoactive drug free days and Glasgow outcome scale.

Enrollment: 160 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Included were patients aged above 18 years, who were expected to stay in the ICU for at least 4 days, between November 2021 and November 2022.

Exclusion criteria

• CNS infections,
• Structural abnormalities of the CNS, known
• Liver or uremic encephalopathy,
• Advanced dementia (Mini mental < 9),
• Psychiatric disorder
• Epilepsy.