Electroencephalography Predictors of Repetitive Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder

Shanghai Mental Health Center

Status

Completed

Conditions

Obsessive Compulsive Disorder (OCD)

Treatments

Device: Continuous theta burst stimulation (cTBS)

Study type

Interventional

Funder types

Other

Identifiers

NCT04432246

SMHC-OCD-007

Details and patient eligibility

About

This study used electroencephalogram (EEG) to predict the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with obsessive-compulsive disorder.

Full description

Repetitive Transcranial Magnetic Stimulation (rTMS), as a relatively mature non-invasive neuromodulation technology, has been recommended for the treatment of patients with refractory OCD in multinational guidelines. However, due to the treatment setting and the patient's feature, nearly half of the patients have no significant changes after rTMS treatment.

In order to better predict the outcome of rTMS and improve the treatment efficiency, this project intends to look for markers that have a predictive effect at baseline or early treatment. Electroencephalogram (EEG) is a cheap and fast method that usually occurs before the symptoms change, thus it is possible to determine whether the patient has responded to the intervention.

In this project, the supplementary motor area (SMA) is selected as the stimulation target. The individual head magnetic resonance image positioning and navigation and rTMS compatible real-time EEG acquisition technology are used to monitor the resting state of EEG and rTMS single pulse stimulation and changes in neural networks before and after treatment. This is a preliminary exploration looking for effective predictive indicators of efficacy in EEG and the relationship between EEG and symptoms changes. In order to lay the foundation for further research and guide clinical treatment.

Enrollment

30 patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age>18 years old;
DSM-5 criteria for OCD;
Y-BOCS total score > or = 16 ->or＝9 yrs education

Exclusion criteria

any additional current psychiatric comorbidity, except for obsessive-compulsive personality disorder serious suicide risk;
the inability to receive rTMS because of metallic implants, or history of seizures，or history of head injury, or history of neurosurgery;
any major medical disease;
pregnancy or nursing of an infant;
participation in current clinical study;
current use of any investigational drug;
TMS/DBS treatment at any point in their lifetime;
history of long-time use of benzodiazepines