Electrohaemodynamic Activity in Epileptic Children : Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis (NIRS Epilepsie)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Epilepsy

Treatments: Device: multimodal high-resolution EEG-NIRS

Study type: Observational

Funder types: Other

Identifiers

NCT02814331

PHRCN11-DR-WALLOIS

Details and patient eligibility

About

Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci

Full description

This study is designed to evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis (HR-EEG, HR-NIRS) to spatial localization of epileptogenic foci in order to perform multimodal mapping and localization of interictal spikes (by HR-EEG source reconstruction) with the clinical prospects of guiding the SEEG electrode implantation strategy prior to surgery in children with drug-refractory partial epilepsy.

Enrollment: 23 patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children between the ages of 6 and 18 years
• with drug-refractory partial epilepsy, presenting interictal spikes on standard EEG recordings.

Exclusion criteria

• Children with a serious congenital malformation.
• Refusal from one of the parents or the child.
• Children with generalized epilepsy or diffuse interictal spikes.
• Children with severely impaired general status and vital functions.
• Children with dermatosis of the face or scalp.
• Children under the age of 6 years or adults over the age of 18 years.

Trial design

23 participants in 2 patient groups

symptomatic partial epilepsy

Description:

whose brain MRI is abnormal multimodal high-resolution EEG-NIRS

Treatment:

Device: multimodal high-resolution EEG-NIRS

not symptomatic partial epilepsy

Description:

whose brain MRI is normal multimodal high-resolution EEG-NIRS

Treatment:

Device: multimodal high-resolution EEG-NIRS