Electromechanical Profiling of the Long-QT Syndrome (LQTS) (EMLoQ)

Maastricht University Medical Centre (MUMC)

Status: Unknown

Conditions: Long QT Syndrome; Sudden Cardiac Death; Ventricular Tachycardia

Treatments: Diagnostic Test: Adenosine and epinephrine, isoprenaline provocation

Study type: Observational

Funder types: Other

Identifiers

NCT04074122

70856

Details and patient eligibility

About

High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.

Full description

Using simultaneous ECG-imaging, speckle-tracking analysis and tissue-phase mapping with MRI we will assess electromechanical dispersion at rest. Regional electromechanical elasticity will be investigated during adenosine and epinephrine, isoprenaline infusions and is postulated to increase sudden cardiac death risk prediction in the individual patient.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

LQTS group (Group 1):

• Diagnosis of LQTS according to the ESC guidelines.
• Genetic testing either already performed or consent to genetic testing (at least 5 major LQTS-related genes tested: KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2).

Control group (Group 2):

> Control subjects with structurally normal hearts.

Exclusion criteria

• Pregnancy, nursing or planning to become pregnant.
• Known allergy or strong reaction to skin electrodes or contrast agent.
• Inability to give informed consent.
• Presence of metal objects in or attached to the body.
• Dialysis.
• Cardiomyopathy.
• Second-degree heart block or higher degrees of block.
• Sick sinus syndrome.
• Asthma.
• Chronic obstructive pulmonary disease.
• Left-main coronary artery disease.
• Unstable coronary artery disease.

Trial design

150 participants in 3 patient groups

Symptomatic LQTS patients

Description:

Pharmacological (adenosine, epinephrine, isoprenaline) provocation, ECG-imaging and tissue-phase mapping using magnetic resonance imaging (TPM-MRI).

Treatment:

Diagnostic Test: Adenosine and epinephrine, isoprenaline provocation

Asymptomatic LQTS patients

Description:

Pharmacological (adenosine, epinephrine, isoprenaline) provocation, ECG-imaging and tissue-phase mapping using magnetic resonance imaging (TPM-MRI).

Treatment:

Diagnostic Test: Adenosine and epinephrine, isoprenaline provocation

Healthy controls

Description:

Pharmacological (adenosine, epinephrine, isoprenaline) provocation, ECG-imaging and tissue-phase mapping using magnetic resonance imaging (TPM-MRI).

Treatment:

Diagnostic Test: Adenosine and epinephrine, isoprenaline provocation