Electrophysiologic Parameters and Biomarkers Predicting Treatment Response in Patients With Major Depressive Disorder

Seoul National University

Status and phase: Unknown; Phase 4

Conditions: Major Depressive Disorder

Treatments: Drug: escitalopram

Study type: Interventional

Funder types: Other

Identifiers

NCT01997580

A121987

Details and patient eligibility

About

To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with major depressive disorder

Full description

Case-control study Repeated measures design

Enrollment: 600 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• DSM-IV-TR major depressive disorder
• aged between 20 and 80
• durg-naive or drug-free

Exclusion criteria

• DSM-IV-TR substance-related disorders (except nicotine)
• significant medical or neurological conditions
• mental retardation or organic brain damage

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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600 participants in 2 patient groups

Escitalopram

Experimental group

Description:

depressed patients receiving escitalopram treatment

Treatment:

Drug: escitalopram

Control

No Intervention group

Description:

healthy controls matched for age, gender, and BMI