Electrophysiological Evaluation of Motor Dysfunction in Liver Cirrhotic Patients

Kasr El Aini Hospital

Status

Completed

Conditions

Liver Cirrhoses

Peripheral Neuropathy

Treatments

Diagnostic Test: Nerve conduction studies and Quantitative EMG ( MUNE and IPA)

Study type

Observational

Funder types

Other

Identifiers

NCT04340999

Electrophysiology - cirrhosis

Details and patient eligibility

About

cross sectional observational study, aimed to assess the electrophysiological function of the motor units in liver cirrhotic patients.

Full description

Liver cirrhosis is a global health problem which could be associated with several neurological manifestations. The associated peripheral neuropathy could be assessed by conventional nerve conduction studies.

Objective: The study aims at early detection of peripheral neuropathy among patients of liver cirrhosis by conventional nerve conduction studies and quantitative EMG methods. In addition, the study aims at finding out correlation between peripheral neuropathy and severity of the liver cirrhosis.

Methods: This a cross-sectional study conducted on fifty-six liver cirrhotic patients, that had been recruited from the Endemic medicine department/outpatient clinics and their age-gender matched sixty-one healthy controls. The recruited patients were clinically assessed .Both conventional nerve conduction studies and quantitative EMG techniques in the form of MUNE calculation, using modified spike -triggered technique and IPA ratio evaluation were performed for the allocated cirrhotic patients.

Enrollment

56 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Both genders.
Age interval range between 18 and 60 years (To avoid maturational changes and aging process on motor unit number).
Liver cirrhotic patients( including compensated and decompensated patients);
- Presenting hematemesis/melena and/or ascites.
- Diagnosis of liver cirrhosis is confirmed by abdominal ultrasound

Exclusion criteria

Patients with identifiable cause of peripheral neuropathy (e.g. diabetic patients) .
Patients who developed hepatocellular carcinoma (to avoid para-neoplastic syndrome e.g. peripheral neuropathy)
Patients with other non-hepatic chronic illness such as: patients with renal disease (to avoid other causes of metabolic neuropathies).