Electrophysiology of the Human Pituitary Gland

Leiden University Medical Center (LUMC)

Status

Terminated

Conditions

Endocrine; Deficiency

Pituitary Adenoma

Pituitary Tumor

Diabetes Insipidus Cranial Type

Treatments

Procedure: Micro-electrode measurement

Study type

Interventional

Funder types

Other

Identifiers

NCT05338125

P19.032

Details and patient eligibility

About

Measurment of electrophysiological properties of the human pituitary gland during removal of a pituitary adenoma. Assessment if these properties are sufficient for intra-operative identification of different tissues.

Full description

In this study, patients undergoing a surgical resection of a pituitary adenoma as part of standard care will undergo an extra measurement of the electrophysiological properties of the pituitary gland. A single-unit microlectrode will be introduced and placed in the adenoma tissue, anterior piuitary lobe and posterior pituitary lobe. Apart from this measurement, no other interventions are performed and standard care will continue. Six months after measurements the patients chart will be assessed for the occurrence of remission and endocrine deficiencies.

An assessment will be made if these properties are distinctive enough to allow intra-operative identification of the different tissues and thereby increase chances of maximal tumour removal and decrease chance of endocrine deficiencies.

Enrollment

1 patient

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female patients undergoing transsphenoidal surgery for pituitary adenoma.
Identification of the posterior lobe on preoperative MRI. This is most common in patients with micro-adenomas or small macroadenomas.
Age >18 years

Exclusion criteria