Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis

Nanjing University School of Medicine

Status: Unknown

Conditions: Organ Failure, Multiple; Acute Pancreatitis

Study type: Observational

Funder types: Other

Identifiers

NCT03282253

ESCDEPDSSAP

Details and patient eligibility

About

In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.

Enrollment: 216 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission;
2. APACHEII score is more than 8 and Ranson score is greater than 3;
3. Age 18-75;
4. Obtaining informed consent.

Exclusion criteria

1. Pregnancy pancreatitis;
2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.