Elimination of Albumin-Bound Substances by MARS and Prometheus

Medical University of Graz

Status: Completed

Conditions: Liver Failure

Treatments: Device: Prometheus (FPSA, Fractionated Plasma Separation and Adsorption); Device: MARS (Molecular Adsorbents Recirculating System)

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00407004

EAT

Details and patient eligibility

About

This trial compares the efficacy of two artificial liver support systems, MARS (Molecular Adsorbents Recirculating System) and Prometheus (FPSA, Fractionated Plasma Separation and Adsorption), in removing albumin-bound substances such as bilirubin, bile acids, and cytokines.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• consecutive patients with acute-on-chronic liver failure (severe deterioration of chronic liver disease) unresponsive to standard medical treatment for >=48 hours

Exclusion criteria

• arterial hypotension
• extrahepatic malignancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)