Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis (DIADSORBMAB)

Heinrich-Heine University, Duesseldorf

Status: Unknown

Conditions: Acute Kidney Injury; Bacterial Infection

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02533609

2015-02-ENDVERSION

Details and patient eligibility

About

Acute kidney injury (AKI) requiring renal replacement therapy is common in critically ill patients. The major causes of AKI are severe sepsis and septic shock requiring effective antibiotic treatment. Patients with sepsis on ICUs usually are haemodynamically instable so that renal replacement therapy is applied using continuous techniques. In recent years, the efficacy of renal replacement therapies has improved, namely by using regional citrate anticoagulation which improves filter lifetime and filter patency. At present, the extent of removal of antibiotic drugs using citrate-anticoagulated CVVHD in critically ill patients has not been investigated thoroughly. Thus, the investigators want to investigate

1. whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during citrate-anticoagulated CVVHD per se
2. whether filter patency during citrate-anticoagulated CVVD remains stable during a treatment period of 72 h

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intensive care patients with acute kidney injury requiring continous renal replacement therapy with citrate-anticoagulation
• Age > 18 y

Exclusion criteria

• < 18 y
• Pregnancy
• Contraindications against citrate-anticoagulation or continous renal replacement therapy

Trial design

30 participants in 2 patient groups

Piperacillin/Tazobactam

Description:

Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics

Imipenem/Cilastatin

Description:

Patients undergoing continuous veno-venous renal replacement therapy and treated with this antibiotics