Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy

Heinrich-Heine University, Duesseldorf

Status

Unknown

Conditions

Acute Kidney Injury

Critical Illness

Sepsis

Treatments

Other: Monitoring of antibiotic drug removal

Study type

Observational

Funder types

Other

Identifiers

NCT02611271

2015-11-Studienanmeldung

Details and patient eligibility

About

Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate

whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

Full description

Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial.

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Intensive care patients with severe sepsis or septic shock and acute kidney injury requiring continuous renal replacement therapy and cytokine adsorption
Age > 18 y

Exclusion criteria