Elimination of Protein-bound Uremic Retention Solutes by Prometheus Artificial Hepatic System Versus Conventional Dialysis

Ghent University Hospital (UZ)

Status: Withdrawn

Conditions: Renal Failure, Chronic

Treatments: Device: Dialysis with different artificial devices

Study type: Interventional

Funder types: Other

Identifiers

NCT00262353

2004/416

Details and patient eligibility

About

Comparison of the efficacy of dialysis by conventional dialysis versus Prometheus artificial hepatic system

Full description

After inclusion, patients will be dialysed with low-flux artificial kidneys. 1 week of dialysis exists of 3 days of dialysis. In week 4, day 2, patients will be treated once with the Prometheus artificial hepatic system or with high-flux dialysis. The other days low-flux kidneys will be used. Week 5 and 6 are a wash-out period. Week 7 is identical to week 4 but the other system than in week 4 is used. Blood samples are taken at regular moments in week 3, week 4 (day 2) and week 7 (day 2).

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable patients
• At least 3 months on dialysis
• Arterio-venous fistula

Exclusion criteria

• Diabetic patients
• Malignancies
• Acute illnesses

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)