Elite Sport and Development of Asthma

Bispebjerg Hospital

Status and phase: Completed; Phase 4

Conditions: Asthma

Treatments: Drug: Seretide; Drug: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00262587

(KF) 01 262958

2005-061

Details and patient eligibility

About

International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects. It is unclear whether the increased prevalence of asthma in elite athletes reflects "traditional asthma" or whether it is a special form of "sports asthma". The treatment of elite athletes with asthma seems to vary widely, and only a few studies have focused on the treatment of elite athletes with asthma. Further knowledge of the pathogenesis of sports asthma would lead to a greater understanding and better treatment of the condition. This study will investigate the type of airway inflammation in elite athletes and examine the effect of treatment with inhaled steroids in combination with long-acting beta-agonists versus placebo in the same group.

Enrollment: 18 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elite athletes
• Informed consent
• Doctor diagnosed asthma

Exclusion criteria

• Current smoker or more than 10 pack-years
• Pregnancy, breast feeding or planning pregnancy during the study.
• ICS within the last 4 weeks prior to visit 1.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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18 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Placebo inhaler (sugar powder)

Treatment:

Drug: Placebo

Seretide

Active Comparator group

Description:

Seretide inhaler

Treatment:

Drug: Seretide