Elsamitrucin (SPP 28090) in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

University of Southern California

Status and phase

Completed

Phase 2

Conditions

Non-Hodgkin's Lymphoma

Treatments

Drug: Elsamitrusin

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00184080

13NHL-04-1

Details and patient eligibility

About

The purpose of this study is to evaluate the safety of an experimental drug called Elsamitrucin in people with non-Hodgkin's lymphoma and to see if it can shrink their tumors. Elsamitrucin has not been approved by the Food and Drug Administration (FDA). However, the FDA is permitting the use of this drug for this study.

Enrollment

7 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed NHL both B and T-cell that is refractory to or has relapsed after standard therapy or for which there is no known effective treatment.
CT or MRI scans confirming measurable tumor size (lymph node must be >1.0 cm in its longest transverse diameter). Measurement by PE is acceptable, in the case of palpable and reproducibly measurable tumors. Patients with CLL/smal lymphocytic lymphoma are eligible without bidimensional measurable disease.
ECOG Performance Status 0-2
Age greater or equal to 18 years of old
AGC greater or equal to 1.0; platelets greater or equal to 75,000;Ggb greater or equal to 9.0. (Lower values may be accepted for cytopenias due to bone marrow involvement by lymphoma, after discussion with sponsor)
Bilirubin less or equal to 2.0; SGOT and SGPT less of equal to 3 times upper limit of normal
Creatinine <1.5; BUN <25
Expected survival >6 months

Exclusion criteria

Prior therapy with Elsamitrucin
Any therapy for lymphoma, including chemotherapy, antibody therapy, RT, or any investigational therapy within 28 days prior to study drug administration
Steroid therapy within the last 4 weeks prior to study drug administration
Evidence of clinically significant uncontrolled condition/s and/or is considered by investigator to be unable to tolerate the required therapy or procedures
Known AIDS syndrome or HIV-associated complex (severely depressed immune system)
Prior or other current malignancy within 5 years, except for adequately treated cone-biopsied in-situ cervical cancer or resected basal cell or squamous cell skin cancer
Any current medical or psychiatric disease that would prevent informed consent and expected cooperation of the patient for therapy and follow-up
Pregnant or lactating women.