Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract

Northwell Health

Status

Enrolling

Conditions

Essential Tremor

Treatments

Device: Deep Brain Stimulation

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04758624

HSC-MS-20-0739

Details and patient eligibility

About

The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation

Enrollment

72 estimated patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

the diagnosis of Essential Tremor, made by a movement disorder neurologist, where tremor is not secondary to any disease process or traumatic insult
distal appendicular tremor, with minimal proximal component
tremor refractory to multiple medication regimens and/or where the medications cause intolerable side effects
tremor judged to be severely impacting their quality of life.

Exclusion criteria

significant neurological disorder
significant dementia or neurocognitive limitations as assessed by neuropsychiatry (when necessary)
severe psychiatric illness with suicidal ideations
previous surgery to destroy the target region of the brain
surgical contraindications to DBS
current major medical problems that affect brain anatomy,neurochemistry, or function, e.g., liver insufficiency, kidney insufficiency, cardiovascular problems, systemic infections, cancer, hypothyroidism, auto-immune diseases, and any current of history of brain disorder (seizure disorder, stroke, dementia, meningitis, encephalitis, degenerative neurologic diseases and head injury with loss of consciousness for any period of time)
family history of hereditary neurologic disorder, besides essential tremors ET
floating metallic objects in the body
pregnancy
alcohol or substance abuse/dependence in the past 6 months.