Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles (AMOS)

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Terminated

Conditions: Euploid Embryos

Study type: Observational

Funder types: Other

Identifiers

NCT03128580

1703-VLC-021-EL

Details and patient eligibility

About

The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.

Full description

Effects of ovarian stimulation on human embryo quality is still a subject of study. When natural and stimulated cycles have been compared, no differences have been observed in terms of embryo cleavage capacity, oocyte and embryo aneuploidy rate or incidence of aneuploidy in aborted foetuses. When mild and conventional doses of gonadotropins have been compared, a higher proportion of good morphological quality embryos are observed in the former. On the contrary, we showed that ovarian stimulation does not increase significantly the embryo aneuploidy rate in IVF derived human embryos when unstimulated and stimulated cycles were compared in oocyte donors. In this study, we want to compare the embryo aneuploidy rate between unstimulated and stimulated cycles in infertile patients, subjected to both IVF cycles with blastocyst biopsy and NGS-PGS. A comparison of the morphokinetics will also be performed.

Enrollment: 40 patients

Sex: Female

Ages: 30 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women
• 30-38 years old (inclusive)
• with regular menstrual cycles (25-35 days)
• AntiMülleriana Hormone >5 pmol/L.
• Undergoing IVF treatment

Exclusion criteria

• BMI >30 kg/m2
• repeated miscarriages
• implantation failure
• uterine or adnexal pathology
• Unable to be treated with gonadotrophins for the ovarian hyperstimulation
• history of low response to ovarian hyperstimulation
• participation in another study with PGS for monogenic pathology
• Cryptozoospermia in male partner

Trial design

40 participants in 2 patient groups

Natural Cycle

Description:

The patient will not undergo hyperstimulation rather a natural cycle

Stimulated Cycle

Description:

The 80 patients will undergo hyperstimulation cycle as per the clinical practice planned for the patient.