Embryo DNA Repair Capacity Project

Reproductive Medicine Associates of New Jersey

Status: Completed

Conditions: Infertility

Treatments: Genetic: double strand break

Study type: Observational

Funder types: Other

Identifiers

NCT03953859

RMA-UK-01

Details and patient eligibility

About

The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

Full description

The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Enrollment: 6 patients

Sex: All

Ages: 21 to 42 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
• IVF couples: any couples proceeding with a routine IVF cycle

Exclusion criteria

• less than 21 years of age
• inability to provide informed consent

Trial design

6 participants in 2 patient groups

Gamete donors

Description:

healthy male and female game donors to undergo routine gamete donation process

Treatment:

Genetic: double strand break

Infertile Couple

Description:

Couples undergoing routine IVF to treat their infertility