Embryo Implantation After Induced Endometrial Injury

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Completed

Conditions: Sterility

Treatments: Procedure: Scratching

Study type: Interventional

Funder types: Other

Identifiers

NCT01955356

1306-C-119-CV/IVI Valencia

Details and patient eligibility

About

Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.

The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF

Full description

Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown.

We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques.

For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.

Enrollment: 600 patients

Sex: Female

Ages: 19 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 19-44 aged women
• 19-29.9 Kg/m2.
• 1st or 2nd fresh embryo transfer ( egg donation).
• 1 or 2 blastocysts available.
• written agreement.
• > or = 6 mms endometrial thickness.

Exclusion criteria

• Premature ovarian failure.
• Endometrial pathology.
• Insufficient endometrial development.
• Hydrosalpinx
• Mullerian malformations.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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600 participants in 2 patient groups

Scratching

Experimental group

Description:

induced endometrial injury

Treatment:

Procedure: Scratching

No scratching

No Intervention group

Description:

None intervention