Embryo Selection Using Non-invasive Metabolomic Analysis Versus Morphology

Eugonia

Status and phase: Completed; Phase 4

Conditions: Embryo Viability

Treatments: Procedure: non-invasive metabolomic profiling; Other: morphological evaluation

Study type: Interventional

Funder types: Other

Identifiers

NCT01490515

metabolomics

Details and patient eligibility

About

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The investigators intended to investigate if embryo assessment using non-invasive metabolomic profiling leads to increased implantation rates compared to routine morphology evaluation alone.

Full description

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The aim of the present study was to determine whether embryo selection using non-invasive metabolomic profiling as an adjunct to morphology leads to increased implantation rates compared to routine morphology evaluation alone.

Enrollment: 125 patients

Sex: Female

Ages: 18 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with at least 4 fertilized oocytes

Exclusion criteria

• patients with less that 4 fertilized oocytes

Trial design

125 participants in 2 patient groups

Morphology embryo evaluation

Active Comparator group

Description:

To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Treatment:

Other: morphological evaluation

non-invasive metabolomic profiling

Experimental group

Description:

To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Treatment:

Procedure: non-invasive metabolomic profiling