EmbryoGlue as an Embryo Transfer Medium

University of Oxford

Status: Unknown

Conditions: Infertility

Treatments: Biological: EmbryoGlue® (laboratory culture medium); Biological: Standard control medium

Study type: Interventional

Funder types: Other

Identifiers

NCT03332680

NDOG-17/NW/0272

Details and patient eligibility

About

In Vitro Fertilisation (IVF) is an increasingly common treatment for infertility. Clinics which offer IVF are continuously trying to improve their success rates, measured by the numbers of IVF cycles which result in the birth of a live baby.

One factor which is thought to have contributed to the success of IVF is the improvements in the embryo culture media, that is, the fluid in which the embryo resides in the laboratory before being replaced into a woman's womb. This trial seeks to identify if IVF cycles in which a particular culture media called EmbryoGlue is used have better results when compared to IVF cycles in which a conventional embryo transfer media is used.

Enrollment: 730 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Couples having embryo transfer for fertility treatment

Exclusion criteria

• Cycles in which elective freezing of all embryos is clinically indicated (e.g. severe risk of OHSS, biopsy patients)
• Use of donor gametes
• Having endometrial scratch technique this cycle
• Concurrent participation in clinical trial(s)
• Previously randomised to this study
• Planned self-fund of EmbryoGlue as transfer media

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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730 participants in 2 patient groups

EmbryoGlue® (laboratory culture medium)

Experimental group

Description:

laboratory culture medium laboratory embryo culture medium, embryos are placed in this media prior to transfer into uterus via embryo transfer procedure to facilitate IVF. EmbryoGlue contains Hyaluronic acid.

Treatment:

Biological: EmbryoGlue® (laboratory culture medium)

Standard control medium

Active Comparator group

Description:

laboratory culture medium In standard procedure embryos are placed in a media prior to transfer into uterus via embryo transfer procedure to facilitate IVF.

Treatment:

Biological: Standard control medium