EMD for Treatment of Proximal Class-II Furcation Involvements (OFD)

Universidade Estadual Paulista Júlio de Mesquita Filho

Status: Completed

Conditions: Generalized Aggressive Periodontitis

Treatments: Procedure: Enamel matrix derivative proteins; Procedure: Open Flap debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT03320135

UEPJMF ICT

Details and patient eligibility

About

The aim of the present study is to evaluate the clinical response of proximal furcations treated with enamel matrix derivative proteins (EMD).

Full description

Proximal class-II furcation represents a challeng to periodontal therapy. Studies show that the ultrasonic non-surgical therapy doesn't work in these defects and the guided tissue regeneration therapy with membranes also demonstrates an unpredictable improvement. Therefore, enamel matrix derivative proteins (EMD) have been proposed as a periodontal regenerative procedure due to their fundamental role in cementum development.

Enrollment: 34 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of generalized aggressive periodontitis (Armitage, 1999; American Academy of Periodontology, 2015);
• Have undergone a first approach for periodontal treatment (full-mouth ultrasonic debridement);
• Presence of one proximal class-II furcation presenting probing depth > 4 mm and bleeding on probing ;
• Good general health;
• Agree to participate in the study and sign the informed consent form (TCLE) after explaining the risks and benefits;

Exclusion criteria

• Systemic problems (cardiovascular alterations, blood dyscrasias, immunodeficiency - ASA III / IV / V) that contraindicate the periodontal procedure;
• Have used antibiotics and anti-inflammatories in the last six months;
• Smoke ≥ 10 cigarettes/day;
• Pregnant or lactating;
• Chronic use of medications that may alter the response of periodontal tissues;
• Indication of antibiotic prophylaxis for dental procedures;

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups

Enamel matrix derivative proteins

Active Comparator group

Description:

Open flap debridement to enamel matrix derivative application in proximal class-II furcation.

Treatment:

Procedure: Open Flap debridement

Procedure: Enamel matrix derivative proteins

Open Flap Debridement

Active Comparator group

Description:

Open flap debridement in proximal class-II furcation.

Treatment:

Procedure: Open Flap debridement