Emotion and Motivation in Patients With Psychosis

University Hospital, Strasbourg, France

Status: Terminated

Conditions: Schizophrenia

Treatments: Other: Electroencephalogram; Behavioral: Cognitive tasks; Behavioral: subjective evaluation scales

Study type: Interventional

Funder types: Other

Identifiers

NCT02853019

6152

Details and patient eligibility

About

Anhedonia and avolition reflect emotional and motivational disorders, respectively. However, if these disorders play a major role in the symptomatology of schizophrenia, their mechanisms remain poorly understood, and existing treatments are inefficient on these symptoms. The literature suggests that the impairment does not concern emotion or motivation per se, but rather their influence on cognition. This project aims at using recent advances in the fundamental domain to better understand the cognitive and neuronal mechanisms of the patients' alterations, and especially how emotion and motivation influence cognition in schizophrenia.

Enrollment: 41 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia

Exclusion criteria

• addiction problem
• invalidating visual sensory problems
• neurological history
• for the healthy volunteers: psychiatric history

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 2 patient groups

Healthy volunteers

Sham Comparator group

Description:

Healthy volunteers

Treatment:

Behavioral: subjective evaluation scales

Behavioral: Cognitive tasks

Other: Electroencephalogram

Patients with schizophrenia

Experimental group

Description:

Patients with schizophrenia

Treatment:

Behavioral: subjective evaluation scales

Behavioral: Cognitive tasks

Other: Electroencephalogram