EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Myoclonus-Dystonia; DYT11

Study type: Observational

Funder types: Other

Identifiers

NCT05671068

C22-18

2022-A00786-37 (Other Identifier)

Details and patient eligibility

About

Background:

Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.

Objective:

To investigate the neural correlates of cognition and emotion in DYT-SGCE.

Design:

Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.

Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.

Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.

Full description

Eligibility:

DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.

Enrollment: 47 patients

Sex: All

Ages: 15 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For all participants:

• Age between 15-60 years
• Able to give informed consent.

For patients:

• An established diagnostic of DYT-SGCE
• No change in medication (related to DYT-SGCE) for a month

For controls:

• No neurological symptoms
• No medication except oral contraception

Exclusion criteria

• No deprivation of liberty
• Inability to give a consent
• Established cognitive alteration
• Contraindication to MRI (per MRI safety checklist)
• Severe chronic psychiatric illness

Trial design

47 participants in 2 patient groups

DYT-SGCE

Description:

Patients with myoclonus dystonia (DYT-SGCE)

Healthy volunteers

Description:

Control group