Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Major Depressive Disorder; General Anxiety Disorder

Treatments: Device: fMRI

Study type: Observational

Funder types: Other

Identifiers

NCT03084042

UESTC-neuSCAN-23

Details and patient eligibility

About

This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and healthy controls; 3) Examine the biomarkers predicting successful therapy or not.

Enrollment: 105 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• GAD:

  1. Diagnosis of Generalized Anxiety Disorder (GAD) according to DSM V criteria in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
  2. Duration of the current episode > 3 weeks

• MDD:

  1. Diagnosis of current major depressive disorder in a structured clinical interview for DSM-V Axis I disorders (SCID I; APA, 2014) and a confirmatory clinical interview
  2. Duration of the current episode > 4 weeks

Exclusion criteria

• GAD: diagnosis of any other psychiatric Axis I disorder (except GAD) as a principal diagnosis within the past six months
• MDD: diagnosis of any other psychiatric Axis I disorder (except MDD) as a principal diagnosis within the past six months

Trial design

105 participants in 3 patient groups

Depression patients (MDD)

Description:

Patients with diagnosis of major depression according to DSM criteria

Treatment:

Device: fMRI

Anxiety patients (GAD)

Description:

Patients with generalized anxiety disorder according to DSM criteria

Treatment:

Device: fMRI

Healthy controls

Description:

Demographically matched healthy controls.

Treatment:

Device: fMRI