Emotional Perceptual Training as a Treatment for Social Anxiety: Behavioral and Neural Evidence. (PTL)

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Florida State University

Status

Completed

Conditions

Anxiety Disorders and Symptoms
Social Anxiety Disorder

Treatments

Behavioral: Gender Discrimination
Behavioral: Perceptual Retraining

Study type

Interventional

Funder types

Other

Identifiers

NCT03437317
PTL-2017.21521

Details and patient eligibility

About

The Perceptual Training Study is a series of studies performed with the purpose of identifying a potential avenue for treatment of mood disorders, particularly anxiety-based mood disorders. The underlying theme is that neural representations may be threat-oriented, and may also be generalized to non-threatening cues by means of similarity to threatening representations. These may result in anxiety symptoms from innocuous cues. The idea behind the perceptual training is to create a divorce between the threat representations and cues which should be considered non-threatening, enhancing perceptual acuity and potentially reducing anxiety symptoms.

Enrollment

154 patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Right-handed
  • Normal or corrected-to-normal vision

Exclusion criteria

  • History of a diagnosed neurological or Diagnostic and Statistical Manual of Mental Disorders - IV Axis I disorder
  • Currently taking prescribed psychoactive drugs, including anti-depressants or anxiolytics.
  • Having electrically, magnetically, or mechanically activated implants (e.g. cardiac pacemakers), due to incompatibility with MRI and MEG systems.
  • Pregnancy or suspected pregnancy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

154 participants in 5 patient groups

Active - MEG
Experimental group
Description:
Participants completed 1 session of 8 Perceptual Retraining blocks following an instructional presentation.
Treatment:
Behavioral: Perceptual Retraining
Control - MEG
Sham Comparator group
Description:
Participants completed 1 session of 8 blocks of Gender Discrimination Task.
Treatment:
Behavioral: Gender Discrimination
Active - 3 Behavior/EEG
Experimental group
Description:
Participants completed 3 sessions of Perceptual Retraining following an instructional presentation. The first session included 6 blocks of perceptual training, and the second session included 12 blocks of perceptual training. No perceptual training was performed in session 3. Sessions were spaced approximately 7 days apart, with a minimum of 3 days and a maximum of 14 days apart.
Treatment:
Behavioral: Perceptual Retraining
Active - 1 Behavior/MEG
Experimental group
Description:
Participants completed 1 session of 6 Perceptual Retraining blocks following an instructional presentation.
Treatment:
Behavioral: Perceptual Retraining
Control - 3 Behavior/MEG
Sham Comparator group
Description:
Participants completed 3 sessions of a Gender Discrimination Task. The first session included 6 blocks of gender discrimination task, and the second session included 12 blocks of the gender discrimination task. No gender discrimination task was performed in session 3. Sessions were spaced approximately 7 days apart, with a minimum of 3 days and a maximum of 14 days apart.
Treatment:
Behavioral: Gender Discrimination

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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