Emotional Proactive Brain Study in Adults With Autism Spectrum Condition (PREDEMAUT)

Grenoble Alpes University Hospital Center (CHU)

Status

Completed

Conditions

Autism Spectrum Disorder

Treatments

Other: EEG

Study type

Observational

Funder types

Other

Identifiers

NCT04069676

2019-A01145-52 (Other Identifier)

38RC19.131

Details and patient eligibility

About

This project aims:

to study behavioral and cerebral activity specificity (latency and amplitude of evoked potentials, time frequency maps and cerebral connectivity) in predictive process (top-down regulation) during visual recognition of static and dynamic stimuli in adults participants with autism spectrum conditions compared to typically developed participants.
to study the relation between predictive process and autonomous response (heart activity and electrodermal activity)
to explore potential sex differences between autistic males and females

Full description

Once eligibility criteria would have been verified, information on the study will be given and non opposition of the participant will be collected.Then, the participant will be comfortably installed in order to pass the Landolt C task (visual acuity task) on a computer. If his vision is normal, electroencephalogram (EEG), electrocardiogram (ECG) and electrodermal activity (EDA) of participants, will be recorded during visual processing and recognition tasks. Stimuli will include emotional and non emotional pictures and films, filtered in coarse-to-fine versus fine-to-coarse sequences in order to stimulate or not predictive process described by Bar (2007).

The participant will also have to complete an abbreviated version of the Wechsler Adult Intelligence Scale, IVth edition (Wechsler, 2003), and the Autism Spectrum Quotient (Baron-Cohen et al., 2001) if he never did it before. The aim is to pair as much as possible group by IQ and to verify that control participants don't present autistic traits above the Autism Spectrum Quotient cutoff. Groups will also be paired by age and education level.

Enrollment

94 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

affiliation to the french social protection care
information and non opposition of the participant
information and non opposition of tutor/curator if the case presented
normal or corrected to normal vision
capacity to understand and apply instruction required by the task
no participation in another research
for autistic person: formal diagnosis of autism spectrum condition (autism/asperger/PDD-NS) according to CIM-10/DSM-IV/DSM-5 criteria

Exclusion criteria