Emotional Proactive Processing in Bipolar Disorder (PROEMO_BP)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Bipolar II Disorder; Bipolar I Disorder; Bipolar Disorder

Treatments: Behavioral: Emotional Stroop Task

Study type: Observational

Funder types: Other

Identifiers

NCT04561622

2019-A03026-51 (Other Identifier)

38RC19.387

Details and patient eligibility

About

The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects. These could contribute to some of the emotional processing biases that can be observed in these patients. To achieve this goal, two behavioral tasks will be administer (emotional stroop and emotional stimuli categorization task) to bipolar patients and control subjects, and their performances will be compared.

Full description

This is a case-control non-interventional study comparing bipolar patients to matched healthy controls during one assessment visit at the University Hospital of Grenoble.

The experimentation phase takes place in three stages: first, the experimenter collects demographic data (age and level of study, lack of medical history and treatments that may interfere with the task). For bipolar subjects, it also collects the type of bipolarity, the type and date of the last episode, the age of the onset of the disease and the treatment.

Secondly, the subject performs a classic Stroop task lasting 3 to 5 minutes, including instructions.

Finally, the subject performs the two main tasks: the emotional Stroop task lasting about 20 minutes and then the task of emotional stimuli categorization lasting about 15 minutes.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right-handed
• Francophones
• Bipolar disorder diagnosis (for patients) according to DSM-5 / CIM-10 criteria
• Affiliation to the French social security insurance

Exclusion criteria

• uncorrected perceptual disturbance
• psychiatric disorders other than bipolarity as the main psychiatric disorder or a condition which may affect the tasks proposed for the patients' group
• subject under legal protection
• subject deprived of freedoms by a judicial or administrative decision
• drug abuse less than 12 hours before the assessment

Trial design

60 participants in 2 patient groups

Bipolar patients

Description:

Bipolar patients (type I,II, NOS) of the bipolar disorder expert center of CHU Grenoble Alpes.

Treatment:

Behavioral: Emotional Stroop Task

Healthy controls

Description:

Volunteers without any psychiatric disease matching inclusion criteria

Treatment:

Behavioral: Emotional Stroop Task