Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit

Clalit Health Services

Status: Enrolling

Conditions: Septic Patients Admitted to the ICU

Treatments: Other: empiric antibiotic therapy

Study type: Observational

Funder types: Other

Identifiers

NCT05924126

MMC-0155-23

Details and patient eligibility

About

Sepsis is one of the most common causes of ICU admission. About 5-15% of patients admitted to the hospital with an infection will have sepsis, and about 30-40% of them will have septic shock. About 34% of septic patients and about 53% of patients with septic shock will die within 28 days of admission. Broad-spectrum empiric antibiotic treatment (depending on the source of infection and patient risk factors) is one of the cornerstones of sepsis management. According to the recommendations of the surviving sepsis campaign, empiric antibiotic treatment should be given within one hour of the patient's arrival for patients with sepsis or septic shock. Administration of inappropriate antibiotics in the first 24 hours of admission was found in 34% of septic patients in various studies, and administration of inappropriate antibiotics (or when administered in delay) was found to be associated with increased morbidity and mortality.

In this study, we will assess the proportion of patients who were admitted to the ICU due to sepsis or septic shock and received empiric antibiotic treatment which, in retrospect, according to the growth in the cultures later on, was inappropriate. We will also assess the therapeutic results in these patients - mainly significant morbidity and mortality within 28 days, and compare them to the group of patients who received appropriate antibiotic therapy. We would also like to assess what were the possible reasons for inappropriate empiric antibiotic treatment, in order to draw conclusions to reduce the rate of these cases.

Enrollment: 155 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• All patients admitted to the general ICU due to sepsis or septic shock between 1/1/20 and 31/12/20

Exclusion Criteria: Patients who were admitted due to other non-infectious etiologies

Trial design

155 participants in 2 patient groups

septic patients who recieved appropriate empiric antibiotics

Treatment:

Other: empiric antibiotic therapy

septic patients who recieved inappropriate empiric antibiotics