Emulsion Droplet Physical State on Postprandial Lipemia and Satiety

University of Guelph

Status

Completed

Conditions

Satiety

Postprandial Lipemia

Treatments

Other: Emulsion with solid droplets

Other: Emulsion with liquid droplets

Study type

Interventional

Funder types

Other

Identifiers

NCT03515590

1801005

Details and patient eligibility

About

The purpose of this study is to compare the changes in blood lipids and feelings of satiety after consumption of oil-in-water emulsions in which the droplets are in either the liquid or solid (i.e. crystalline) states.

Full description

A double blinded randomized cross-over acute meal study will be carried out in which 15 healthy male participants will attend two study visits, separated by at least one week. On each study visit, fasted participants will consume either the solid or the liquid emulsion, in a randomized order. Both emulsions tested will have the exact same composition only differing in the physical state of the lipid emulsions, in order to isolate the impact of physical state, specifically, on metabolic response. Postprandial lipemia and satiety will be measured for 6 hours after consumption of the test beverage. The study meals will include crushed acetominophen, the appearance of which will be measured in plasma as a measure of liquid content gastric emptying. Participants will be asked to maintain their usual lifestyle habits throughout the study, with some changes in the 48 hour period leading up to each of the two visits.

Enrollment

15 patients

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

BMI of 18 - 26 kg/m2
generally healthy
non-smoking
non to moderate alcohol drinkers
fasting plasma cholesterol level <5.2 mmol/L
plasma triacylglycerol level <1.7 mmol/L
plasma glucose level <5.6 mmol/L

Exclusion criteria

History of major medical conditions
taking prescription medications/ over the counter medications
taking natural health products/ dietary supplements (other than a multivitamin)
oral antibiotic use in the previous 3 months
planning to take oral antibiotics in the next 3 months
food allergy/anaphylactic/life-threatening allergy
smokers/ regular users of recreational drugs
elite/ training athletes
significant weight loss/ gain during the past 3 months
previous reaction/ sensitivity to acetaminophen
inability to avoid taking acetaminophen for 48 hours
sensitivity to the artificial sweetener Sugar Twin® Sucralose and artificial vanilla extract
not willing to consume Sugar Twin® Sucralose or Artificial vanilla.