Endoarterial Treatment in Combination With Percutaneous Thermoablation for Medium-sized and Oligonodular Hepatocellular Carcinomas

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Carcinoma, Hepatocellular

Study type: Observational

Funder types: Other

Identifiers

NCT04172194

19-PT-02

Details and patient eligibility

About

Background: The association of transcatheter arterial chemotherapy infusion (TAC) with percutaneous ablation (PT) has been introduced as a method to increase the ablative zone. The aim of this study was to evaluate the efficacy of PT and TAC performed in a single session for HCCs between 30 and 50 mm or oligonodular up to 30 mm.

Methods: Thirty patients with a histologically proven HCC, uninodular between 30 and 50 mm or oligonodular (n≤3) up to 30 mm, treatment-naïve and non-metastatic, received combination treatment ("PT+TAC group"). A "control" group consisted of 34 patients with uninodular HCC up to 30 mm without any poor prognostic criteria treated with PT alone ("PT group").

Enrollment: 64 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hepatocellular carcinoma pouved by pathology,

Exclusion criteria

• metastases

Trial design

64 participants in 2 patient groups

PT Group

Description:

patients with hepatocellular carcinoma treated by percutaneous thermoablation alone

PT+TAC group

Description:

patients with hepatocellular carcinoma treated by pecutaneous thermoablation comined in a single session with trans-arterial chemoembolization