Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus

Alexandria University

Status: Completed

Conditions: Periodontitis; Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT05667051

#256

Details and patient eligibility

About

Aim of the current study was to evaluate Endocan biomarker level in gingival crevicular fluid of patients with stage 1 or 2 (mild to moderate) periodontitis with controlled type 2 diabetes mellitus (DM) and compare it to that in DM free periodontitis patients.

Enrollment: 42 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Probing pocket depths (PPD) ≤ 5 mm.
• Clinical attachment level (CAL) ≤ 4 mm.
• Type 2 DM, for at least the past 3 years.
• HbA1c ≤ 7%.

Exclusion criteria

• Uncontrolled Diabetes Mellitus.
• Systemic antibiotic or anti-inflammatory medication use in the previous 2 months.
• Non-surgical periodontal therapy in the previous 6 months.
• Surgical periodontal therapy in the previous 12 months.
• Use of calcium channel blockers, phenytoin, or cyclosporine.
• Pregnancy.
• Smokers

Trial design

42 participants in 2 patient groups

Controlled type 2 diabetes mellitus

Diabetes mellitus free patients