Endocan Blood Level in Pulmonary Circulation (ENDOPULM)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Cardiac Surgery; Cardiopulmonary Bypass; Lung

Study type: Observational

Funder types: Other

Identifiers

NCT04616820

ENDOPULM

Details and patient eligibility

About

Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.

Full description

The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery.

The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned on pump coronary artery bypass surgery
• Non opposition

Exclusion criteria

• Age < 18 years old
• Emergent surgery
• Valvular replacement surgery
• Combined cardiac surgery
• Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease
• Patients with valvular problems, in particular aortic insufficiency
• Patients who refuse to participate
• Legal inability or disability
• Patients who will probably not cooperate for the study
• Pregnancy and/or breast feeding
• Patients not in the Social security system
• Patients in the exclusion period of another study