Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors

Semmelweis University

Status: Unknown

Conditions: Thyroid Diseases; Cortisol Deficiency; End-stage Heart Failure; Endocrine System Diseases; Diabetes Insipidus; End Stage Lung Disease

Treatments: Procedure: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT04351945

VSZÉK TRANSPLANT

Details and patient eligibility

About

The aim of this study is to assess the impact of endocrine changes and their correction on survival and organ function in heart and lung transplant recipients. This study also features an investigation of the hormone levels and hormonal replacement therapy of the donors to study its role in the function of the transplanted hearts and lungs.

Thyroid hormones (TSH, thyroxine, tri-iodothyronine), cortisol and the antidiuretic hormone will be studied.

The former two hormone levels will be defined in the recipients just before transplantation and three days later. In the case of the donors all three hormones will be recorded at the time of the explantation. The investigators would like to record the hormonal replacement therapy in all our patients as well to see it's effect on survival and on the transplanted organ function.

After the transplantation during the hospital stays all the important hemodynamic parameters, laboratory parameters, the result of the medical imagings, the medication, the length of ICU and hospital stay and the complications were recorded.

Recipients will be followed for five years. Organ function will be assessed every three month for a year, after than every six month for further four years. Investigator would like to record the result of the cardiac echocardiography, spirometries, imaging, and complications. Our purpose is to compare these results against the endocrine disorders and the replacement therapy.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age admitted for heart or lung transplantation and their organ donors.
• written consent from the recipients

Exclusion criteria

• lack of consent
• non-evaluable patient due to insufficient clinical information

Trial design

100 participants in 1 patient group

Blood test

Description:

Patients will have a blood test to define hormone levels.

Treatment:

Procedure: Blood test