Endocytoscopy of Upper Gastrointestinal Tract in Acute Graft-versus-host Disease: a Pilot Study

Shanghai Jiao Tong University

Status: Completed

Conditions: Endocytoscopy

Treatments: Procedure: ECS Group

Study type: Interventional

Funder types: Other

Identifiers

NCT06247891

2023309

Details and patient eligibility

About

The goal of this clinical trial is to test the assess the diagnostic effectiveness of endocytoscopy in patients with underlying UGI aGvHD. The main question it aims to answer is: the effectiveness of ECS for diagnosing UGI aGvHD. Participants will undergo endoscopy, endocytoscopic evaluation and biopsy simultaneously. If there is a comparison group: Researchers will compare endoscopic, endocytoscopic and pathologic findings of these patients.

Enrollment: 14 patients

Sex: All

Ages: 14+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged ≥ 14 years
• developed UGI symptoms within first three months after engraftment or during the tapering of immunosuppressive agents

Exclusion criteria

• < 14 year
• with underlying gastrointestinal disease before allo-HSCT
• incomplete medical information

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

Control Group

Other group

Treatment:

Procedure: ECS Group