Endodontic Microsurgery With the Use of L-PRF Block

Universitaire Ziekenhuizen KU Leuven

Status

Enrolling

Conditions

Apical Periodontitis

Apical Periodontal Cyst

Treatments

Procedure: Endodontic Microsurgery

Study type

Interventional

Funder types

Other

Identifiers

NCT05379010

S63971

Details and patient eligibility

About

Full description

This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions. The trial design is an open randomized controlled clinical trial with two groups. Half of the participants will receive EMS with L-PRF Block (experimental group), the other half without (control group).

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Provision of Informed Consent
Patients from 18 years old
Patients in need of an EMS
EMS is the only option to cure the periapical lesion
A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT

Exclusion Criteria

Unlikely to be able to comply with the study procedures, as judged by the investigator
Orthograde endodontic (re)treatment is indicated
Known or suspected current malignancy
History of chemotherapy within 5 years prior to study
History of radiation in the head and neck region
History of other metabolic bone diseases
History of bleeding disorders
HIV disease
Hepatitis B or C
Systemic disease (osteoporosis, diabetes...)