Endogenous Lithium Clearance in Acute Kidney Injury

University Hospital of North Norway

Status: Completed

Conditions: Acute Kidney Injury Due to Sepsis; Proximal Tubule Function; Lithium Clearance

Treatments: Diagnostic Test: Lithium clearance

Study type: Observational

Funder types: Other

Identifiers

NCT05982340

03055 PVO

Details and patient eligibility

About

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness.

Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Full description

Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ICU patients diagnosed with AKI, without AKI and healthy controls

Exclusion criteria

Trial design

20 participants in 2 patient groups

Group 1

Description:

ICU patients with AKI

Treatment:

Diagnostic Test: Lithium clearance

Group 2

Description:

ICU patients with normal renal function

Treatment:

Diagnostic Test: Lithium clearance