Endogenous Modulation of Pain and Stretch Tolerance

University College of Northern Denmark

Status: Completed

Conditions: Pain Threshold

Treatments: Other: Static stretch (SS); Other: Exercise induced hypoalgesia (EIH); Other: Rest; Other: Conditioned pain modulation (CPM)

Study type: Interventional

Funder types: Other

Identifiers

NCT03886883

UniversityCND1

Details and patient eligibility

About

This study investigates the role of two endogenous inhibitory mechanisms; exercise-induced hypoalgesia (EIH) and a conditioning painful stimulus (CPM) on passive joint range of motion, passive resistive torque and pain sensitivity. The study is a randomized, repeated-measures cross-over study.

Full description

The increase in range of motion following stretching is related to changes in the tolerance to stretch. The mechanistic relationships behind these changes in subject sensation are however unknown but could be related to endogenous modulation of pain.

Enrollment: 19 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

Exclusion criteria

• Substance abuse, History of neurological or mental disabilities, Lack of ability to comply with instructions, Delayed onset of muscle soreness.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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19 participants in 4 patient groups

Exercise-induced hypoalgesia (EIH)

Experimental group

Description:

Exercise-induced hypoalgesia - isometric muscle contractions of the hand flexors

Treatment:

Other: Exercise induced hypoalgesia (EIH)

Static stretch (SS)

Active Comparator group

Description:

A static stretch of the knee flexors

Treatment:

Other: Static stretch (SS)

Rest

Sham Comparator group

Description:

No intervention

Treatment:

Other: Rest

Conditioning painful stimulus (CPM)

Experimental group

Description:

Conditioned pain modulation - cold pressure test

Treatment:

Other: Conditioned pain modulation (CPM)