Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)

Kaplan Medical Center

Status: Unknown

Conditions: Infertility; Recurrent Implantation Failure

Treatments: Procedure: endometrial biopsy/ies

Study type: Interventional

Funder types: Other

Identifiers

NCT01278706

kmc110154CTIL

Details and patient eligibility

About

Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.

In this study, the investigators will compare different temporal timing of the biopsies with regards to the menstrual cycle and their affect on the success rates of the treatment.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal menstrual cycle
• between 1-6 previous failed IVF cycles
• normal hormonal profile

Exclusion criteria

• intrauterine procedure in last 3 months
• hydrosalpinx
• intrauterine lesion /malformation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 4 patient groups

no treatment

No Intervention group

one biopsy, proliferative phase

Experimental group

Treatment:

Procedure: endometrial biopsy/ies

one biopsy, secretory phase

Experimental group

Treatment:

Procedure: endometrial biopsy/ies

two biopsies

Experimental group

Treatment:

Procedure: endometrial biopsy/ies