Endometrial Fluid Study in Natural Cycles: a Prospective Observational Study

Anecova

Status: Completed

Conditions: Endometrial Fluid

Study type: Observational

Funder types: Industry

Identifiers

NCT03909230

NCV-VIS-001

Details and patient eligibility

About

This study is designed to collect information about the characteristics of endometrial fluid at day 2 and day 4 post-ovulation in normal fertile women.

Full description

Implantation rates have stabilised around 35% in IVF and a current key rate limiting step is achieving successful implantation of the embryo. 1/3 of implantation failures are estimated to be caused by a problem with the receptivity of the endometrium. In recent years, several measurable parameters have been reported to assess endometrial receptivity. However, one parameter remains undescribed, the endometrial fluid viscosity.

It is generally believed that the viscosity change post ovulation is influenced by the luteal phase endocrine milieu, and it is possible that the viscosity of the endometrial fluid has an impact on implantation.

Enrollment: 30 patients

Sex: Female

Ages: Under 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: ≤ 35 years
• Women eligible and qualified for egg donation at IVIRMA Bilbao
• Proven fertile (having given birth to at least one spontaneously conceived normal child)
• Signed written consent including sharing of anonymized data

Exclusion criteria

• Contraindications for egg donation according to IVIRMA Bilbao guidelines

Trial design

30 participants in 2 patient groups

Day 2 post ovulation

Description:

Ultrasound of the endometrium, Endometrial fluid sample, Blood sample

Day 4 post ovulation

Description:

Ultrasound of the endometrium, Endometrial fluid sample, Blood sample