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Endometrial Genomic Profile in Endometrial Priming

I

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status

Completed

Conditions

Genomic Human Endometrial Expression Profile

Treatments

Procedure: endometrial biopsy

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT01778452
VLC18012013

Details and patient eligibility

About

The aim of this study is to analyse genomics profile expression in endometrium under different endometrial priming for recipients.

Full description

We analyze the genomic profile of egg donors in different endometrial priming protocols, compared with natural cycle, including the conventional single long acting GnRH agonist injection in the mid luteal phase of the previous cycle of the endometrial priming and the single daily antagonist injection (Cetrorelix 0.25 mg) administered in the early follicular phase followed by endometrial priming. Endometrial biopsy will be taken in luteinizing hormone

  • 7 or with P4 +5 in cases with endometrial priming with oestrogens therapy.

Enrollment

6 patients

Sex

Female

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 6 egg healthy volunteer egg donors.
  • Volunteers.
  • 18-35 years old
  • Healthy.
  • BMI <28.

Exclusion criteria

    • BMI > 28
  • Smokers-

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

6 participants in 3 patient groups

Natural cycle
Active Comparator group
Description:
Natural cycle endometrial biopsy, lh+7
Treatment:
Procedure: endometrial biopsy
Antagonist cycle + endometrial priming.
Experimental group
Description:
Antagonist cycle + endometrial priming for egg donation program. endometrial biopsy, p4+5
Treatment:
Procedure: endometrial biopsy
Agonist cycle + endometrial priming.
Experimental group
Description:
Agonist cycle + endometrial priming for egg donation program endometrial biopsy, p4+5
Treatment:
Procedure: endometrial biopsy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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