Endometrial Injury and IVF-ET Outcome

Bangalore Assisted Conception Centre

Status

Completed

Conditions

Infertility

Treatments

Procedure: PIPELLE ENDOMETRIAL SAMPLING

Study type

Interventional

Funder types

Other

Identifiers

NCT00796341

endometrial injury study

Details and patient eligibility

About

Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.

Full description

Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF.

Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle.

Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.

SAMPLE SIZE: 100 PATIENTS (50 in each group).

Enrollment

99 patients

Sex

Female

Ages

18 to 37 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Previous failed In-vitro fertilization embryo transfer cycle
Patients who are good responders and have good quality embryos in the previous attempts
Age of patients upto 37yrs

Exclusion criteria

Those detected to have endometrial tuberculosis in the past, including those treated with Antituberculosis treatment
Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma
Those with sonographically detected hydrosalpinx