Endometrial Injury and Single Embryo Transfer

Karadeniz Technical University

Status: Completed

Conditions: Primary Infertility

Treatments: Device: Endometrial injury

Study type: Interventional

Funder types: Other

Identifiers

NCT01851876

2011/20

Details and patient eligibility

About

Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.

Full description

Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.

Enrollment: 118 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• woman age under 35 years
• history of primary infertility
• normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
• having grade I or II embryos for transfer
• agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.

Exclusion criteria

• endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
• using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
• patients who did not proceed to follicle retrieval
• severe male infertility requiring TESA/TESA
• mullerian tract anomalies
• a history of endometrial instrumentation or surgery within a month of the study
• not agree to undergo endometrial biopsy during the COH cycle.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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118 participants in 2 patient groups

Endometrial injury

Experimental group

Description:

The patients in this group will be subjected to endometrial injury procedure in preceding IVF cycle.

Treatment:

Device: Endometrial injury

No endometrial injury

No Intervention group

Description:

The patients in this group will not be subjected to endometrial injury procedure in presiding IVF cycle. The patients will be stimulated with standard IVF protocol.