Endometrial Injury for Assisted Reproduction

University of Sao Paulo

Status and phase: Terminated; Phase 3

Conditions: Infertility

Treatments: Procedure: Endometrial injury; Procedure: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT01132144

HCRP10340/09

Details and patient eligibility

About

The objective of this study is to evaluate the effect of endometrial injury performed prior ovulation induction for assisted reproductive techniques main outcomes.

Enrollment: 158 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women who will start assisted reproductive techniques with planned fresh embryo transfer.
• Age between 18 and 38 years.
• Written informed consent.

Exclusion criteria

• None

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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158 participants in 2 patient groups

Endometrial injury group

Experimental group

Description:

Endometrial biopsy was performed once with a pipelle de Cornier® in the month before initiating controlled ovarian stimulation.

Treatment:

Procedure: Endometrial injury

Control group

Sham Comparator group

Description:

Introduction of the speculum and wiping of the cervix with gaze for 30 seconds.

Treatment:

Procedure: Control group