Endometrial Local Injury and Implantation Failure

Yazd Research & Clinical Center for Infertility

Status

Completed

Conditions

Infertility

Treatments

Procedure: Endometrial Biopsy

Procedure: Endometrial biopsy

Study type

Interventional

Funder types

Other

Identifiers

NCT00837733

1551354

Details and patient eligibility

About

The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

Full description

In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group.

The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Enrollment

115 patients

Sex

Female

Ages

15 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred

Exclusion criteria