Endometrial Local Injury to Improve the Outcome of Embryo Transfer

Navy General Hospital, Beijing

Status: Unknown

Conditions: Female Infertility Due to Nonimplantation of Ovum

Treatments: Procedure: Endometrial local injury

Study type: Interventional

Funder types: Other

Identifiers

NCT02306395

LY-2014

Details and patient eligibility

About

The purpose of this study is to determine whether edometrial local injury improves the outcome of embryo transfer,and to find out more evidence about the time of trauma,the way of intervention,and the possible mechanism.

Full description

It is important to evaluate the efficacy of endometrial local injury in assisted reproductive technology(ART),especially on the patients of recurrent implantation failure. Although most trials proved the effectiveness of the intervention of local injury, the subjects of these trials are rarely the patients of repeated implantation failure(RIF). Moreover, the mechanism of endometrial injury is not clear.Our trial may provide further basis for this purpose by comparing to the quality of endometrium in two-dimensional ultrasound.If the technique demonstrates efficacy, it would help the patients with RIF caused by poor conditions of endometrium to deal with the problem of infertility.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with RIF(≥2) of embyo transfer and uneven echo of endometrium on HCG day(12-14 days)
• Without operation history of uterine cavity in the previous three months
• Who agree to join in the study

Exclusion criteria

• Women more than 40 years or less than 20 years
• With infectious diseases or endocrine diseases
• Who refuse to participate in the experiment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Endometrial local injury

Experimental group

Description:

Endometrial local injury is carried in the first 3-5 days after menstrual period at the same time of hysteroscopy.

Treatment:

Procedure: Endometrial local injury

The blank group

No Intervention group

Description:

Any processing does not carry on the endometrium in the first 3-5 days after menstrual period except hysteroscopy.