Endometrial Scratch Effect on Pregnancy Rates in Patients Undergoing Egg-donation IVF

Procreatec

Status: Completed

Conditions: EMBRYO IMPLANTATION

Treatments: Procedure: Endometrial scratch

Study type: Interventional

Funder types: Other

Identifiers

NCT03108157

ENDOSCRATCH

Details and patient eligibility

About

Clinical trial about the effect of endometrial scratch on pregnancy rates in patients undergoing a treatment with in-vitro fertilization with donor eggs, when doing the endometrial biopsy during the cycle prior to the embryo transfer.

Full description

The aim of this clinical trial is to investigate whether an endometrial scratch during the cycle prior to embryo transfer cycle is effective or not in increasing pregnancy rates. Previous studies about this issue have not shown clear conclusions about the effectiveness of this method.

The endometrial scratch is a simple technique that consists in performing a mild injury to all the internal walls of the uterus with a Pipelle Cournier.

To achieve the trial objective, all participating patients are randomly divided into two groups. Once patients decide to participate in the trial, they are assigned to each group according to the randomization list:

Group A: Patients with transfer of fresh embryos after taking an endometrium biopsy during the previous cycle and then following the conventional preparation protocol.

Group B: Patients with transfer of fresh embryos with the conventional preparation protocol.

Enrollment: 352 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female undergoing IVF treatment with donor eggs

Exclusion criteria

• Severe male factor ( less tan 2 million spermatozoa per ml )
• Uterine abnormalities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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352 participants in 2 patient groups

GROUP A: intervention group

Experimental group

Description:

Patients will be performed an endometrial scratch with Pipelle Cournier 3 to 4 weeks before the embryo transfer and then they will follow the conventional preparation protocol to receive embryos coming from an egg donation treatment.

Treatment:

Procedure: Endometrial scratch

GROUP B: no intervention group

No Intervention group

Description:

Patients will receive the conventional preparation protocol to receive embryos coming from an egg donation treatment.