Endometrial Scratching in Couples With Unexplained Subfertility (ESUS)

Mansoura University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Subfertility

Treatments: Procedure: scratching

Study type: Interventional

Funder types: Other

Identifiers

NCT01412606

AG2

Details and patient eligibility

About

Endometrial scratching in luteal phase of a spontaneous menstrual cycle may increase pregnancy rate in women with unexplained infertility.

Enrollment: 105 patients

Sex: Female

Ages: 20 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• women aged between 20 and 39 years with at least one year of infertility
• regular menstruation with the length of the cycle between 22-34 days and ovulation confirmed by appropriately timed mid-luteal progesterone
• fertile semen variables
• bilateral tubal patency (demonstrated by laparoscopy or hysterosalpingography).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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105 participants in 2 patient groups, including a placebo group

Scrathcing

Experimental group

Description:

scratching of endometrium on day 21-26 of a spontaneous menstrual cycle

Treatment:

Procedure: scratching

Control

Placebo Comparator group

Description:

Uterine sounding on day 21-26 of a spontaneous menstrual cycle

Treatment:

Procedure: scratching